Branched Latent Neural Operators

08/04/2023
by   Matteo Salvador, et al.
0

We introduce Branched Latent Neural Operators (BLNOs) to learn input-output maps encoding complex physical processes. A BLNO is defined by a simple and compact feedforward partially-connected neural network that structurally disentangles inputs with different intrinsic roles, such as the time variable from model parameters of a differential equation, while transferring them into a generic field of interest. BLNOs leverage interpretable latent outputs to enhance the learned dynamics and break the curse of dimensionality by showing excellent generalization properties with small training datasets and short training times on a single processor. Indeed, their generalization error remains comparable regardless of the adopted discretization during the testing phase. Moreover, the partial connections, in place of a fully-connected structure, significantly reduce the number of tunable parameters. We show the capabilities of BLNOs in a challenging test case involving biophysically detailed electrophysiology simulations in a biventricular cardiac model of a pediatric patient with hypoplastic left heart syndrome. The model includes a purkinje network for fast conduction and a heart-torso geometry. Specifically, we trained BLNOs on 150 in silico generated 12-lead electrocardiograms (ECGs) while spanning 7 model parameters, covering cell-scale, organ-level and electrical dyssynchrony. Although the 12-lead ECGs manifest very fast dynamics with sharp gradients, after automatic hyperparameter tuning the optimal BLNO, trained in less than 3 hours on a single CPU, retains just 7 hidden layers and 19 neurons per layer. The mean square error is on the order of 10^-4 on an independent test dataset comprised of 50 additional electrophysiology simulations. This paper provides a novel computational tool to build reliable and efficient reduced-order models for digital twinning in engineering applications.

READ FULL TEXT

page 8

page 9

research
06/08/2023

Real-time whole-heart electromechanical simulations using Latent Neural Ordinary Differential Equations

Cardiac digital twins provide a physics and physiology informed framewor...
research
10/08/2019

DeepONet: Learning nonlinear operators for identifying differential equations based on the universal approximation theorem of operators

While it is widely known that neural networks are universal approximator...
research
10/06/2022

Fast and robust parameter estimation with uncertainty quantification for the cardiac function

Parameter estimation and uncertainty quantification are crucial in compu...
research
06/02/2020

Deep learning-based reduced order models in cardiac electrophysiology

Predicting the electrical behavior of the heart, from the cellular scale...
research
10/25/2021

A machine learning method for real-time numerical simulations of cardiac electromechanics

We propose a machine learning-based method to build a system of differen...
research
05/13/2019

Fast Parameter Inference in a Biomechanical Model of the Left Ventricle using Statistical Emulation

A central problem in biomechanical studies of personalised human left ve...

Please sign up or login with your details

Forgot password? Click here to reset