Suitability of an inter-burst detection method for grading hypoxic-ischemic encephalopathy in newborn EEG
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Electroencephalography (EEG) is an important clinical tool for grading injury caused by lack of oxygen or blood to the brain during birth. Characteristics of low-voltage waveforms, known as inter-bursts, are related to different grades of injury. This study assesses the suitability of an existing inter-burst detection method, developed from preterm infants born <30 weeks of gestational age, to detect inter-bursts in term infants. Different features from the temporal organisation of the inter-bursts are combined using a multi-layer perceptron (MLP) machine learning algorithm to classify four grades of injury in the EEG. We find that the best performing feature, percentage of inter-bursts, has an accuracy of 59.3 duration of inter-bursts in the MLP produces a testing accuracy of 77.8 similar performance to existing multi-feature methods. These results validate the use of the preterm detection method in term EEG and show how simple measures of the inter-burst interval can be used to classify different grades of injury.
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