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08/31/2023
Introduction of accelerated BOIN design and facilitation of its application
Purpose: During discussions at the Data Science Roundtable meeting in Ja...
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05/24/2023
Dynamic Borrowing Method for Historical Information Using a Frequentist Approach for Hybrid Control Design
Information borrowing from historical data is gaining attention in clini...
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02/13/2023
Adaptive Cohort Size Determination Method for Bayesian Optimal Interval Phase I/II Design to Shorten Clinical Trial Duration
Recently, the strategy for dose optimization in oncology has shifted to ...
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01/11/2023
Frailty Model with Change Point for Survival Analysis
We propose a novel frailty model with change points applying random effe...
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12/05/2022
Variable Selection using Inverse Survival Probability Weighting
In this paper, we propose two variable selection methods for adjusting t...
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11/01/2022
Comparison of Baseline Covariate Adjustment Methods for Restricted Mean Survival Time
The restricted mean survival time is a clinically easy-to-interpret meas...
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02/09/2022
Data-Dependent Early Completion of Dose Finding Trials for Drug-Combination
We propose a data-dependent early completion of dose finding trials for ...
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01/14/2022
Application of Multi-Armed Bandits to Model-assisted designs for Dose-Finding Clinical Trials
We consider applying multi-armed bandits to model-assisted designs for d...
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01/10/2022
Easy confidence interval formulas for network meta-analysis and adjustment of confidence intervals for a small number of studies
We propose simple formulas of confidence intervals for the Wald statisti...
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10/05/2021
Adaptive design for identifying maximum tolerated dose early to accelerate dose-finding trial
Purpose: The early identification of maximum tolerated dose (MTD) in pha...
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09/22/2021
Early completion based on multiple dosages to accelerate maximum tolerated dose-finding
Background: Phase I trials desire to identify the maximum tolerated dose...
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09/22/2021