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04/16/2023
Second Order Markov multistate models
Multistate models (MSM) are well developed for continuous and discrete t...
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11/04/2022
Design of Trials with Composite Endpoints with the R Package CompAREdesign
Composite endpoints are widely used as primary endpoints in clinical tri...
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06/20/2022
Adaptive clinical trial designs with blinded selection of binary composite endpoints and sample size reassessment
For randomized clinical trials where a single, primary, binary endpoint ...
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08/29/2020
Design of phase III trials with long-term survival outcomes based on short-term binary results
Pathologic complete response (pCR) is a common primary endpoint for a ph...
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02/04/2020
A general class of two-sample statistics for binary and time-to-event outcomes
We propose a class of two-sample statistics for testing the equality of ...
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01/10/2020
Decision tool and Sample Size Calculator for Composite Endpoints
Summary points: - This article considers the combination of two binary...
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07/25/2019
Non-constant hazard ratios in randomized controlled trials with composite endpoints
The hazard ratio is routinely used as a summary measure to assess the tr...
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07/03/2018