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11/28/2022
Point estimation for adaptive trial designs II: practical considerations and guidance
In adaptive clinical trials, the conventional end-of-trial point estimat...
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08/24/2022
Online multiple hypothesis testing for reproducible research
Modern data analysis frequently involves large-scale hypothesis testing,...
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05/08/2022
Some performance considerations when using multi-armed bandit algorithms in the presence of missing data
When using multi-armed bandit algorithms, the potential impact of missin...
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02/08/2022
Online error control for platform trials
Platform trials evaluate multiple experimental treatments under a single...
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05/18/2021
Point estimation for adaptive trial designs
Recent FDA guidance on adaptive clinical trial designs defines bias as "...
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10/13/2020
Conditional Power and Friends: The Why and How of (Un)planned, Unblinded Sample Size Recalculations in Confirmatory Trials
Adapting the final sample size of a trial to the evidence accruing durin...
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06/28/2020
A review of Bayesian perspectives on sample size derivation for confirmatory trials
Sample size derivation is a crucial element of the planning phase of any...
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05/01/2020
Response-adaptive randomization in clinical trials: from myths to practical considerations
Response-adaptive randomization (RAR) is part of a wider class of data-d...
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04/03/2020
Graphical approaches for the control of generalised error rates
When simultaneously testing multiple hypotheses, the usual approach in t...
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09/19/2018
Online control of the false discovery rate in biomedical research
Modern biomedical research frequently involves testing multiple related ...
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03/14/2018