Discriminative Pattern Mining for Breast Cancer Histopathology Image Classification via Fully Convolutional Autoencoder
Accurate diagnosis of breast cancer in histopathology images is challenging due to the heterogeneity of cancer cell growth as well as of a variety of benign breast tissue proliferative lesions. In this paper, we propose a practical and self-interpretable invasive cancer diagnosis solution. With minimum annotation information, the proposed method mines contrast patterns between normal and malignant images in unsupervised manner and generates a probability map of abnormalities to verify its reasoning. Particularly, a fully convolutional autoencoder is used to learn the dominant structural patterns among normal image patches. Patches that do not share the characteristics of this normal population are detected and analyzed by one-class support vector machine and 1-layer neural network. We apply the proposed method to a public breast cancer image set. Our results, in consultation with a senior pathologist, demonstrate that the proposed method outperforms existing methods. The obtained probability map could benefit the pathology practice by providing visualized verification data and potentially leads to a better understanding of data-driven diagnosis solutions.
02/22/2019 ∙ by Xingyu Li, et al. ∙ 16 ∙ share
Because combat environments change over time and technology upgrades are widespread for ground vehicles, a large number of vehicles and equipment become quickly obsolete. A possible solution for the U.S. Army is to develop fleets of modular military vehicles, which are built by interchangeable substantial components also known as modules. One of the typical characteristics of module is their ease of assembly and disassembly through simple means such as plug-in/pull-out actions, which allows for real-time fleet reconfiguration to meet dynamic demands. Moreover, military demands are time-varying and highly stochastic because commanders keep reacting to enemy's actions. To capture these characteristics, we formulated an intelligent agent-based model to imitate decision making process during fleet operation, which combines real-time optimization with artificial intelligence. The agents are capable of inferring enemy's future move based on historical data and optimize dispatch/operation decisions accordingly. We implement our model to simulate an attacker-defender game between two adversarial and intelligent players, representing the commanders from modularized fleet and conventional fleet respectively. Given the same level of combat resources and intelligence, we highlight the tactical advantages of fleet modularity in terms of win rate, unpredictability and suffered damage.
11/09/2018 ∙ by Xingyu Li, et al. ∙ 0 ∙ share
We demonstrate an end-to-end question answering system that integrates BERT with the open-source Anserini information retrieval toolkit. In contrast to most question answering and reading comprehension models today, which operate over small amounts of input text, our system integrates best practices from IR with a BERT-based reader to identify answers from a large corpus of Wikipedia articles in an end-to-end fashion. We report large improvements over previous results on a standard benchmark test collection, showing that fine-tuning pretrained BERT with SQuAD is sufficient to achieve high accuracy in identifying answer spans.
02/05/2019 ∙ by Wei Yang, et al. ∙ 0 ∙ share
Xingyu Liis this you? claim profile