Validating GAN-BioBERT: A Methodology For Assessing Reporting Trends In Clinical Trials

06/01/2021 ∙ by Joshua J Myszewski, et al. ∙ 0

In the past decade, there has been much discussion about the issue of biased reporting in clinical research. Despite this attention, there have been limited tools developed for the systematic assessment of qualitative statements made in clinical research, with most studies assessing qualitative statements relying on the use of manual expert raters, which limits their size. Also, previous attempts to develop larger scale tools, such as those using natural language processing, were limited by both their accuracy and the number of categories used for the classification of their findings. With these limitations in mind, this study's goal was to develop a classification algorithm that was both suitably accurate and finely grained to be applied on a large scale for assessing the qualitative sentiment expressed in clinical trial abstracts. Additionally, this study seeks to compare the performance of the proposed algorithm, GAN-BioBERT, to previous studies as well as to expert manual rating of clinical trial abstracts. This study develops a three-class sentiment classification algorithm for clinical trial abstracts using a semi-supervised natural language process model based on the Bidirectional Encoder Representation from Transformers (BERT) model, from a series of clinical trial abstracts annotated by a group of experts in academic medicine. Results: The use of this algorithm was found to have a classification accuracy of 91.3 with a macro F1-Score of 0.92, which is a significant improvement in accuracy when compared to previous methods and expert ratings, while also making the sentiment classification finer grained than previous studies. The proposed algorithm, GAN-BioBERT, is a suitable classification model for the large-scale assessment of qualitative statements in clinical trial literature, providing an accurate, reproducible tool for the large-scale study of clinical publication trends.

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