Total-effect Test May Erroneously Reject So-called "Full" or "Complete" Mediation

09/16/2023
by   Tingxuan Han, et al.
0

The procedure for establishing mediation, i.e., determining that an independent variable X affects a dependent variable Y through some mediator M, has been under debate. The classic causal steps require that a “total effect” be significant, now also known as statistically acknowledged. It has been shown that the total-effect test can erroneously reject competitive mediation and is superfluous for establishing complementary mediation. Little is known about the last type, indirect-only mediation, aka “full" or “complete" mediation, in which the indirect (ab) path passes the statistical partition test while the direct-and-remainder (d) path fails. This study 1) provides proof that the total-effect test can erroneously reject indirect-only mediation, including both sub-types, assuming least square estimation (LSE) F-test or Sobel test; 2) provides a simulation to duplicate the mathematical proofs and extend the conclusion to LAD-Z test; 3) provides two real-data examples, one for each sub-type, to illustrate the mathematical conclusion; 4) in view of the mathematical findings, proposes to revisit concepts, theories, and techniques of mediation analysis and other causal dissection analyses, and showcase a more comprehensive alternative, process-and-product analysis (PAPA).

READ FULL TEXT

page 1

page 2

page 3

page 4

research
10/13/2021

Path-Free Decomposition for Direct, Indirect and Interaction Effects in Mediation Analysis

Given a binary treatment and a binary mediator, mediation analysis decom...
research
07/21/2021

Improving the Power to Detect Indirect Effects in Mediation Analysis

Causal mediation analysis seeks to determine whether an independent vari...
research
10/28/2019

Estimation and inference for the indirect effect in high-dimensional linear mediation models

Mediation analysis is difficult when the number of potential mediators i...
research
06/28/2023

Mediation with External Summary Statistic Information (MESSI)

Environmental health studies are increasingly measuring endogenous omics...
research
03/01/2022

On the Causal Interpretation of Randomized Interventional Indirect Effects

Identification of standard mediated effects such as the natural indirect...
research
12/22/2022

Estimating network-mediated causal effects via spectral embeddings

The last several years have seen a renewed and concerted effort to incor...

Please sign up or login with your details

Forgot password? Click here to reset