The design and statistical aspects of VIETNARMS: a strategic post-licensing trial of multiple oral direct acting antiviral Hepatitis C treatment strategies in Vietnam

by   L. McCabe, et al.

Background Achieving hepatitis C elimination is hampered by the costs of treatment and the need to treat hard-to-reach populations. Treatment access could be widened by shortening treatment, but limited research means it is unclear which strategies could achieve sufficiently high cure rates to be acceptable. We present the statistical aspects of a multi-arm trial designed to test multiple strategies simultaneously with a monitoring mechanism to detect and stop those with unacceptably low cure rates quickly. Methods The VIETNARMS trial will factorially randomise patients to three randomisations. We will use Bayesian monitoring at interim analyses to detect and stop recruitment into unsuccessful strategies, defined as a >0.95 posterior probability of the true cure rate being <90 stopping guideline, planned the timing of the interim analyses and explored power at the final analysis. Results A beta(4.5, 0.5) prior for the true cure rate produces <0.05 probability of incorrectly stopping a group with true cure rate >90 probability) to stop after  25 low cure rates (80 recruitment. Interim analyses 7, 10, 13 and 18 months after recruitment commences provide good probabilities of stopping inferior groups. For an overall true cure rate of 95 regimen and strategy comparisons using 5 regardless of the control cure rate, and to detect a 5 the ribavirin comparison. Conclusions The operating characteristics of the stopping guideline are appropriate and interim analyses can be timed to detect failing groups at various stages.



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