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Temporal Events Detector for Pregnancy Care (TED-PC): A Rule-based Algorithm to Infer Gestational Age and Delivery Date from Electronic Health Records of Pregnant Women with an

by   Tianchu Lyu, et al.

Objective: To develop a rule-based algorithm that detects temporal information of clinical events during pregnancy for women with COVID-19 by inferring gestational weeks and delivery dates from Electronic Health Records (EHR) from the National COVID Cohort Collaborate (N3C). Materials and Methods: The EHR are normalized by the Observational Medical Outcomes Partnership (OMOP) Clinical Data Model (CDM). EHR phenotyping resulted in 270,897 pregnant women (2018-06-01 to 2021-05-31). We developed a rule-based algorithm and performed a multi-level evaluation to test content validity and clinical validity of the algorithm; and extreme value analysis for individuals with <150 or >300 days of gestation. Results: The algorithm identified 296,194 pregnancies (16,659 COVID-19 174 and 744 without COVID-19 peri-pandemic) in 270,897 pregnant women. For inferring gestational age, 95 (Cohen Kappa = 0.62); 100 temporal information (Cohen Kappa = 1). For inferring delivery dates, the accuracy is 100 extreme length of gestation is 93.3 showed higher prevalence in obesity (35.1 17.0 respiratory distress syndrome (ARDS) (1.8 the characteristics of pregnant women by different timing of COVID-19 with our algorithm: the first to infer temporal information from complete antenatal care and detect the timing of SARS-CoV-2 infection for pregnant women using N3C. Conclusion: The algorithm shows excellent validity in inferring gestational age and delivery dates, which supports national EHR cohorts on N3C studying the impact of COVID-19 on pregnancy.


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