Structural Cumulative Survival Models for Robust Estimation of Treatment Effects Accounting for Treatment Switching in Randomized Experiments

04/27/2022

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by   Andrew Ying, et al.

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We propose an instrumental variable estimator to estimate the treatment causal effect when treatment switching is present in a randomized experiment, under a structural cumulative survival model. Our estimator is robust to violation of the exclusion restriction, a commonly adopted assumption for IV methods that is untestable and usually subject to questioning in practice, especially in an open-label randomized trial. We derive large-sample properties of our proposed estimator, along with inferential tools. We apply the estimator to evaluate the treatment effect of Nucleoside Reverse Transcriptase Inhibitors on a safety outcome in the Optimized Treatment That Includes or Omits NRTIs trial.