Stochastic simulation of pattern formation in growing tissue: a multilevel approach

02/03/2018
by   Stefan Engblom, et al.
0

We take up the challenge of designing realistic computational models of large interacting cell populations. The goal is essentially to bring Gillespie's celebrated stochastic methodology to the level of an interacting population of cells. Specifically, we are interested in how the gold standard of single cell computational modeling, here taken to be spatial stochastic reaction-diffusion models, may be efficiently coupled with a similar approach at the cell population level. Concretely, we target a recently proposed set of pathways for pattern formation involving Notch-Delta signaling mechanisms. These involve cell-to-cell communication as mediated both via direct membrane contact sites as well as via cellular protrusions. We explain how to simulate the process in growing tissue using a multilevel approach and we discuss implications for future development of the associated computational methods.

READ FULL TEXT

page 7

page 10

research
08/23/2010

Proliferating cell nuclear antigen (PCNA) allows the automatic identification of follicles in microscopic images of human ovarian tissue

Human ovarian reserve is defined by the population of nongrowing follicl...
research
07/18/2020

Automated Phenotyping via Cell Auto Training (CAT) on the Cell DIVE Platform

We present a method for automatic cell classification in tissue samples ...
research
06/05/2020

Adipose Cell Differentiation in Explant-derived Cell Culture

Adipose tissue is derived from the embryonic mesenchyme and contains a s...
research
03/08/2021

Synplex: A synthetic simulator of highly multiplexed histological images

Multiplex tissue immunostaining is a technology of growing relevance as ...
research
08/30/2021

Individual and population approaches for calibrating division rates in population dynamics: Application to the bacterial cell cycle

Modelling, analysing and inferring triggering mechanisms in population r...
research
09/18/2019

Generation mechanism of cell assembly to store information about hand recognition

A specific memory is stored in a cell assembly that is activated during ...
research
09/26/2018

On Bioelectric Algorithms: A Novel Application of Theoretical Computer Science to Core Problems in Developmental Biology

Cellular bioelectricity describes the biological phenomenon in which cel...

Please sign up or login with your details

Forgot password? Click here to reset