Statistical evaluation of in-vivo bioassays in regulatory toxicology considering males and females
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The separate evaluation for males and females is the recent standard in in-vivo toxicology for dose or treatment effects using Dunnett tests. The alternative pre-test for sex-by-treatment interaction is problematic. Here a joint test is proposed considering the two sex-specific and the pooled Dunnett-type comparisons. The calculation of either simultaneous confidence intervals or adjusted p-values with the R-package multcomp is demonstrated using a real data example.
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