Quantitative photoacoustic oximetry imaging by multiple illumination learned spectral decoloring

02/22/2021
by   Thomas Kirchner, et al.
2

Significance: Quantitative measurement of blood oxygen saturation (sO_2) with photoacoustic (PA) imaging is one of the most sought after goals of quantitative PA imaging research due to its wide range of biomedical applications. Aim: A method for accurate and applicable real-time quantification of local sO_2 with PA imaging. Approach: We combine multiple illumination (MI) sensing with learned spectral decoloring (LSD); training on Monte Carlo simulations of spectrally colored absorbed energy spectra, in order to apply the trained models to real PA measurements. We validate our combined MI-LSD method on a highly reliable, reproducible and easily scalable phantom model, based on copper and nickel sulfate solutions. Results: With this sulfate model we see a consistently high estimation accuracy using MI-LSD, with median absolute estimation errors of 2.5 to 4.5 percentage points. We further find fewer outliers in MI-LSD estimates compared to LSD. Random forest regressors outperform previously reported neural network approaches. Conclusions: Random forest based MI-LSD is a promising method for accurate quantitative PA oximetry imaging.

READ FULL TEXT

page 3

page 13

page 14

page 17

research
02/15/2019

Estimation of blood oxygenation with learned spectral decoloring for quantitative photoacoustic imaging (LSD-qPAI)

One of the main applications of photoacoustic (PA) imaging is the recove...
research
12/17/2015

Numerical Demultiplexing of Color Image Sensor Measurements via Non-linear Random Forest Modeling

The simultaneous capture of imaging data at multiple wavelengths across ...
research
07/10/2023

Invertible Low-Dimensional Modelling of X-ray Absorption Spectra for Potential Applications in Spectral X-ray Imaging

X-ray interaction with matter is an energy-dependent process that is con...
research
06/11/2023

Moving beyond simulation: data-driven quantitative photoacoustic imaging using tissue-mimicking phantoms

Accurate measurement of optical absorption coefficients from photoacoust...
research
05/25/2018

Qunatification of Metabolites in MR Spectroscopic Imaging using Machine Learning

Magnetic Resonance Spectroscopic Imaging (MRSI) is a clinical imaging mo...
research
06/22/2023

Interferometric lensless imaging: rank-one projections of image frequencies with speckle illuminations

Lensless illumination single-pixel imaging with a multicore fiber (MCF) ...
research
07/11/2016

Inference of Haemoglobin Concentration From Stereo RGB

Multispectral imaging (MSI) can provide information about tissue oxygena...

Please sign up or login with your details

Forgot password? Click here to reset