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Predicting colorectal polyp recurrence using time-to-event analysis of medical records

11/18/2019
by   Lia X. Harrington, et al.
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Identifying patient characteristics that influence the rate of colorectal polyp recurrence can provide important insights into which patients are at higher risk for recurrence. We used natural language processing to extract polyp morphological characteristics from 953 polyp-presenting patients' electronic medical records. We used subsequent colonoscopy reports to examine how the time to polyp recurrence (731 patients experienced recurrence) is influenced by these characteristics as well as anthropometric features using Kaplan-Meier curves, Cox proportional hazards modeling, and random survival forest models. We found that the rate of recurrence differed significantly by polyp size, number, and location and patient smoking status. Additionally, right-sided colon polyps increased recurrence risk by 30 left-sided polyps. History of tobacco use increased polyp recurrence risk by 20 0.65 and identified several other predictive variables, which can inform development of personalized polyp surveillance plans.

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