Online Learning to Estimate Warfarin Dose with Contextual Linear Bandits

07/11/2019
by   Hai Xiao, et al.
0

Warfarin is one of the most commonly used oral blood anticoagulant agent in the world, the proper dose of Warfarin is difficult to establish not only because it is substantially variant among patients, but also adverse even severe consequences of taking an incorrect dose. Typical practice is to prescribe an initial dose, then doctor closely monitor patient response and adjust accordingly to the correct dosage. The three commonly used strategies for an initial dosage are the fixed-dose approach, the Warfarin Clinical algorithm, and the Pharmacogenetic algorithm developed by the IWPC (International Warfarin Pharmacogenetics Consortium). It is always best to prescribe correct initial dosage, motivated by this challenge, this work explores the performance of multi-armed bandit algorithms to best predict the correct dosage of Warfarin instead of trial-and-error procedure. Real data from the Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB) is used, with it a series of linear bandit algorithms and variants are developed and evaluated on Warfarin dataset. All proposed algorithms outperformed the fixed-dose baseline algorithm, and some even matched up the Warfarin Clinical Dosing Algorithm. In addition, a few promising future directions are given for further exploration and development.

READ FULL TEXT

page 1

page 2

page 3

page 4

research
05/06/2021

Evaluating the Effect of Longitudinal Dose and INR Data on Maintenance Warfarin Dose Predictions

Warfarin, a commonly prescribed drug to prevent blood clots, has a highl...
research
03/17/2019

On Multi-Armed Bandit Designs for Phase I Clinical Trials

We study the problem of finding the optimal dosage in a phase I clinical...
research
06/07/2021

Multi-armed Bandit Requiring Monotone Arm Sequences

In many online learning or multi-armed bandit problems, the taken action...
research
09/10/2018

Estimate the Warfarin Dose by Ensemble of Machine Learning Algorithms

Warfarin dosing remains challenging due to narrow therapeutic index and ...
research
01/14/2022

Application of Multi-Armed Bandits to Model-assisted designs for Dose-Finding Clinical Trials

We consider applying multi-armed bandits to model-assisted designs for d...

Please sign up or login with your details

Forgot password? Click here to reset