On ratio measures of population heterogeneity for meta-analyses

09/22/2020

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by   Maxwell Cairns, et al.

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Popular measures of meta-analysis heterogeneity, such as I^2, cannot be considered measures of population heterogeneity since they are dependant on samples sizes within studies. The coefficient of variation (CV) recently introduced and defined to be the heterogeneity variance divided by the absolute value of the overall mean effect does not suffer such shortcomings. However, very large CV values can occur when the effect is small making interpretation difficult. The purpose of this paper is two-fold. Firstly, we consider variants of the CV that exist in the interval (0, 1] making interpretation simpler. Secondly, we provide interval estimators for the CV and its variants with excellent coverage properties. We perform simulation studies based on simulated and real data sets and draw comparisons between the methods.