Multi-View Graph Convolutional Network and Its Applications on Neuroimage Analysis for Parkinson's Disease

05/22/2018

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by   Xi Zhang, et al.

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Parkinson's Disease (PD) is one of the most prevalent neurodegenerative diseases that affects tens of millions of Americans. PD is highly progressive and heterogeneous. Quite a few studies have been conducted in recent years on predictive or disease progression modeling of PD using clinical and biomarkers data. Neuroimaging, as another important information source for neurodegenerative disease, has also arisen considerable interests from the PD community. In this paper, we propose a deep learning method based on Graph Convolution Networks (GCN) for fusing multiple modalities in brain images to distinct PD cases from controls. On Parkinson's Progression Markers Initiative (PPMI) cohort, our approach achieved 0.9537± 0.0587 AUC, compared with 0.6443± 0.0223 AUC achieved by traditional approaches such as PCA.