Morphological Change Forecasting for Prostate Glands using Feature-based Registration and Kernel Density Extrapolation

by   Qianye Yang, et al.

Organ morphology is a key indicator for prostate disease diagnosis and prognosis. For instance, In longitudinal study of prostate cancer patients under active surveillance, the volume, boundary smoothness and their changes are closely monitored on time-series MR image data. In this paper, we describe a new framework for forecasting prostate morphological changes, as the ability to detect such changes earlier than what is currently possible may enable timely treatment or avoiding unnecessary confirmatory biopsies. In this work, an efficient feature-based MR image registration is first developed to align delineated prostate gland capsules to quantify the morphological changes using the inferred dense displacement fields (DDFs). We then propose to use kernel density estimation (KDE) of the probability density of the DDF-represented future morphology changes, between current and future time points, before the future data become available. The KDE utilises a novel distance function that takes into account morphology, stage-of-progression and duration-of-change, which are considered factors in such subject-specific forecasting. We validate the proposed approach on image masks unseen to registration network training, without using any data acquired at the future target time points. The experiment results are presented on a longitudinal data set with 331 images from 73 patients, yielding an average Dice score of 0.865 on a holdout set, between the ground-truth and the image masks warped by the KDE-predicted-DDFs.


Longitudinal Image Registration with Temporal-order and Subject-specificity Discrimination

Morphological analysis of longitudinal MR images plays a key role in mon...

Collaborative Quantization Embeddings for Intra-Subject Prostate MR Image Registration

Image registration is useful for quantifying morphological changes in lo...

Deformable Image Registration using Unsupervised Deep Learning for CBCT-guided Abdominal Radiotherapy

CBCTs in image-guided radiotherapy provide crucial anatomy information f...

Evaluating Registration Without Ground Truth

We present a generic method for assessing the quality of non-rigid regis...

DeepAtrophy: Teaching a Neural Network to Differentiate Progressive Changes from Noise on Longitudinal MRI in Alzheimer's Disease

Volume change measures derived from longitudinal MRI (e.g. hippocampal a...

Learning Multiparametric Biomarkers for Assessing MR-Guided Focused Ultrasound Treatments Using Volume-Conserving Registration

Noninvasive MR-guided focused ultrasound (MRgFUS) treatments are promisi...

Improving Human Sperm Head Morphology Classification with Unsupervised Anatomical Feature Distillation

With rising male infertility, sperm head morphology classification becom...