Meshfree implementation of the cardiac monodomain model through the Fragile Points Method

11/12/2021
by   Konstantinos A. Mountris, et al.
0

Meshfree methods for in silico modelling and simulation of cardiac electrophysiology are gaining more and more popularity. These methods do not require a mesh and are more suitable than the Finite Element Method (FEM) to simulate the activity of complex geometrical structures like the human heart. However, challenges such as numerical integration accuracy and time efficiency remain and limit their applicability. Recently, the Fragile Points Method (FPM) has been introduced in the meshfree methods family. It uses local, simple, polynomial, discontinuous functions to construct trial and test functions in the Galerkin weak form. This allows for accurate integration and improved efficiency while enabling the imposition of essential and natural boundary conditions as in the FEM. In this work, we consider the application of FPM for cardiac electrophysiology simulation. We derive the cardiac monodomain model using the FPM formulation and we solve several benchmark problems in 2D and 3D. We show that FPM leads to solutions of similar accuracy and efficiency with FEM while alleviating the need for a mesh. Additionally, FPM demonstrates better convergence than FEM in the considered benchmarks.

READ FULL TEXT

page 9

page 10

page 11

research
05/14/2020

A New Meshless "Fragile Points Method (FPM)" Based on A Galerkin Weak-Form for 2D Flexoelectric Analysis

A meshless Fragile Points Method (FPM) is presented for analyzing 2D fle...
research
06/28/2023

Convergence analysis of a weak Galerkin finite element method on a Shishkin mesh for a singularly perturbed fourth-order problem in 2D

We consider the singularly perturbed fourth-order boundary value problem...
research
02/26/2023

Implementation of an aeroacoustic simulation pipeline using openCFS-Acoustics and openCFS-Data applied to human phonation

The human phonation process be modeled using the Finite Element Method (...
research
05/21/2019

A new Fragile Points Method (FPM) in computational mechanics, based on the concepts of Point Stiffnesses and Numerical Flux Corrections

In this paper, a new method, named the Fragile Points Method (FPM), is d...
research
06/16/2019

On the determination of ischemic regions in the monodomain model of cardiac electrophysiology from boundary measurements

In this paper we consider the monodomain model of cardiac electrophysiol...

Please sign up or login with your details

Forgot password? Click here to reset