Measurement Error in Meta-Analysis (MEMA) – a Bayesian framework for continuous outcome data

11/14/2020

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by   Harlan Campbell, et al.

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Ideally, a meta-analysis will summarize data from several unbiased studies. Here we consider the less than ideal situation in which contributing studies may be compromised by measurement error. Measurement error affects every study design, from randomized controlled trials to retrospective observational studies. We outline a flexible Bayesian framework for continuous outcome data which allows one to obtain appropriate point and interval estimates with varying degrees of prior knowledge about the magnitude of the measurement error. We also demonstrate how, if individual-participant data (IPD) are available, the Bayesian meta-analysis model can adjust for multiple participant-level covariates, measured with or without measurement error.