lifex-ep: a robust and efficient software for cardiac electrophysiology simulations

08/03/2023
by   Pasquale C. Africa, et al.
0

Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated endeavors of various research teams, comprehensive and user-friendly software programs for cardiac simulations are still in the process of achieving full maturity within the scientific community. This work introduces lifex-ep, a publicly available software for numerical simulations of the electrophysiology activity of the cardiac muscle, under both physiological and pathological conditions. lifex-ep employs the monodomain equation to model the heart's electrical activity. It incorporates both phenomenological and second-generation ionic models. These models are discretized using the Finite Element method on tetrahedral or hexahedral meshes. Additionally, lifex-ep integrates the generation of myocardial fibers based on Laplace-Dirichlet Rule-Based Methods, previously released in Africa et al., 2023, within lifex-fiber. This paper provides a concise overview of the mathematical models and numerical methods underlying lifex-ep, along with comprehensive implementation details and instructions for users. lifex-ep features exceptional parallel speedup, scaling efficiently when using up to thousands of cores, and its implementation has been verified against an established benchmark problem for computational electrophysiology. We showcase the key features of lifex-ep through various idealized and realistic simulations. lifex-ep offers a user-friendly and flexible interface. lifex-ep provides easy access to cardiac electrophysiology simulations for a wide user community. It offers a computational tool that integrates models and accurate methods for simulating cardiac electrophysiology within a high-performance framework, while maintaining a user-friendly interface.

READ FULL TEXT

page 17

page 19

page 21

page 22

page 30

research
01/10/2022

An open tool based on lifex for myofibers generation in cardiac computational models

Modeling the whole cardiac function involves the solution of several com...
research
07/13/2021

Scalable Biophysical Simulations of the Neuromuscular System

The human neuromuscular system consisting of skeletal muscles and neural...
research
01/26/2021

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

Since myocardial fibers drive the electric signal propagation throughout...
research
04/24/2023

lifex-cfd: an open-source computational fluid dynamics solver for cardiovascular applications

Computational fluid dynamics (CFD) is an important tool for the simulati...
research
07/29/2022

lifex: a flexible, high performance library for the numerical solution of complex finite element problems

Numerical simulations are ubiquitous in mathematics and computational sc...
research
10/12/2020

End-to-End Deep Learning for Reliable Cardiac Activity Monitoring using Seismocardiograms

Continuous monitoring of cardiac activity is paramount to understanding ...

Please sign up or login with your details

Forgot password? Click here to reset