Is it who you are or where you are? Accounting for compositional differences in cross-site treatment variation

03/26/2021
by   Benjamin Lu, et al.
0

Multisite trials, in which treatment is randomized separately in multiple sites, offer a unique opportunity to disentangle treatment effect variation due to "compositional" differences in the distributions of unit-level features from variation due to "contextual" differences in site-level features. In particular, if we can re-weight (or "transport") each site to have a common distribution of unit-level covariates, the remaining effect variation captures contextual differences across sites. In this paper, we develop a framework for transporting effects in multisite trials using approximate balancing weights, where the weights are chosen to directly optimize unit-level covariate balance between each site and the target distribution. We first develop our approach for the general setting of transporting the effect of a single-site trial. We then extend our method to multisite trials, assess its performance via simulation, and use it to analyze a series of multisite trials of welfare-to-work programs. Our method is available in the balancer R package.

READ FULL TEXT
POST COMMENT

Comments

There are no comments yet.

Authors

page 1

page 2

page 3

page 4

03/16/2018

Identifying and Estimating Principal Causal Effects in Multi-site Trials

Randomized trials are often conducted with separate randomizations acros...
12/02/2021

Using Ecometric Data to Explore Sources of Cross-Site Impact Variance in Multi-Site Trials

A new method is proposed to explore sources of cross-site impact varianc...
12/09/2021

Covariate Balancing Sensitivity Analysis for Extrapolating Randomized Trials across Locations

The ability to generalize experimental results from randomized control t...
06/13/2020

Efficiently transporting causal (in)direct effects to new populations under intermediate confounding and with multiple mediators

The same intervention can produce different effects in different sites. ...
02/11/2019

A Blockchain Framework for Managing and Monitoring Data in Multi-Site Clinical Trials

The cost of conducting multi-site clinical trials has significantly incr...
12/10/2021

Model-based scenario analysis for effective site-specific weed control on grassland sites

The site-specific management of weeds in grassland is often challenging ...
This week in AI

Get the week's most popular data science and artificial intelligence research sent straight to your inbox every Saturday.