How do dataset characteristics affect the performance of propensity score methods and regression for controlling confounding in observational studies? A simulation study

03/24/2022
by   J. Wilkinson, et al.
0

In observational studies, researchers must select a method to control for confounding. Options include propensity score methods and regression. It remains unclear how dataset characteristics (size, overlap in propensity scores, exposure prevalence) influence the relative performance of the methods, making it difficult to select the best method for a particular dataset. A simulation study to evaluate the role of dataset characteristics on the performance of propensity score methods, compared to logistic regression, for estimating a marginal odds ratio in the presence of confounding was conducted. Outcomes were simulated from logistic and complementary log-log models, and size, overlap in propensity scores, and prevalence of the exposure were varied. Regression showed poor coverage for small sample sizes, but with large sample sizes it was more robust to imbalance in propensity scores and low exposure prevalence than were propensity score methods. Propensity score methods frequently displayed suboptimal coverage, particularly as overlap in propensity scores decreased. These problems were exacerbated at larger sample sizes. Power of matching methods was particularly affected by lack of overlap, low prevalence of exposure, and small sample size. Performance of inverse probability of treatment weighting depended heavily on dataset characteristics, with poor coverage and bias with low overlap. The advantage of regression for large data size was less clear in sensitivity analysis with a complementary log-log outcome generation mechanism and unmeasured confounding, with superior bias and error but lower coverage than nearest neighbour and caliper matching.

READ FULL TEXT

Authors

page 12

page 20

12/12/2019

Sensitivity analysis for bias due to a misclassfied confounding variable in marginal structural models

In observational research treatment effects, the average treatment effec...
01/15/2019

A weighting method for simultaneous adjustment for confounding and joint exposure-outcome misclassifications

Joint misclassification of exposure and outcome variables can lead to co...
12/03/2019

Confounding Adjustment Methods for Multi-level Treatment Comparisons Under Lack of Positivity and Unknown Model Specification

Imbalances in covariates between treatment groups are frequent in observ...
06/07/2020

Propensity score weighting under limited overlap and model misspecification

Propensity score (PS) weighting methods are often used in non-randomized...
03/19/2019

Semiparametric Methods for Exposure Misclassification in Propensity Score-Based Time-to-Event Data Analysis

In epidemiology, identifying the effect of exposure variables in relatio...
02/14/2022

Analyzing whether workplace smoking bans can reduce the probability of smoking

The rapid increase of smoking-related diseases and deaths globally is dr...
04/07/2022

A tutorial for using propensity score weighting for moderation analysis: an application to smoking disparities among LGB adults

Objective. To provide step-by-step guidance and STATA and R code for usi...
This week in AI

Get the week's most popular data science and artificial intelligence research sent straight to your inbox every Saturday.