Hepatocellular Carcinoma Intra-arterial Treatment Response Prediction for Improved Therapeutic Decision-Making

12/01/2019

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by   Junlin Yang, et al.

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This work proposes a pipeline to predict treatment response to intra-arterial therapy of patients with Hepatocellular Carcinoma (HCC) for improved therapeutic decision-making. Our graph neural network model seamlessly combines heterogeneous inputs of baseline MR scans, pre-treatment clinical information, and planned treatment characteristics and has been validated on patients with HCC treated by transarterial chemoembolization (TACE). It achieves Accuracy of 0.713 ± 0.075, F1 of 0.702 ± 0.082 and AUC of 0.710 ± 0.108. In addition, the pipeline incorporates uncertainty estimation to select hard cases and most align with the misclassified cases. The proposed pipeline arrives at more informed intra-arterial therapeutic decisions for patients with HCC via improving model accuracy and incorporating uncertainty estimation.