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Finite element modelling of in-stent restenosis

by   Kiran Manjunatha, et al.

From the perspective of coronary heart disease, the development of stents has come significantly far in reducing the associated mortality rate, drug-eluting stents being the epitome of innovative and effective solutions. Within this work, the intricate process of in-stent restenosis is modelled considering one of the significant growth factors and its effect on constituents of the arterial wall. A multiphysical modelling approach is adopted in this regard. Experimental investigations from the literature have been used to hypothesize the governing equations and the corresponding parameters. A staggered solution strategy is utilised to capture the transport phenomena as well as the growth and remodeling that follows stent implantation. The model herein developed serves as a tool to predict in-stent restenosis depending on the endothelial injury sustained and the protuberance of stents into the lumen of the arteries. Keywords: in-stent restenosis, smooth mucsle cells, platelet-derived growth factor, extracellular matrix, growth


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