Estimation and false discovery control for the analysis of environmental mixtures

03/18/2021 ∙ by Srijata Samanta, et al. ∙ 0

The analysis of environmental mixtures is of growing importance in environmental epidemiology, and one of the key goals in such analyses is to identify exposures and their interactions that are associated with adverse health outcomes. Typical approaches utilize flexible regression models combined with variable selection to identify important exposures and estimate a potentially nonlinear relationship with the outcome of interest. Despite this surge in interest, no approaches to date can identify exposures and interactions while controlling any form of error rates with respect to exposure selection. We propose two novel approaches to estimating the health effects of environmental mixtures that simultaneously 1) Estimate and provide valid inference for the overall mixture effect, and 2) identify important exposures and interactions while controlling the false discovery rate. We show that this can lead to substantial power gains to detect weak effects of environmental exposures. We apply our approaches to a study of persistent organic pollutants and find that our approach is able to identify more interactions than existing approaches.



There are no comments yet.


page 8

page 10

page 12

page 13

page 17

page 18

page 19

page 20

This week in AI

Get the week's most popular data science and artificial intelligence research sent straight to your inbox every Saturday.