Detection of Risk Predictors of COVID-19 Mortality with Classifier Machine Learning Models Operated with Routine Laboratory Biomarkers
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Early evaluation of patients who require special care and high death expectancy in COVID-19 and effective determination of relevant biomarkers on large sample groups are important to reduce mortality. This study aimed to reveal the routine blood value predictors of COVID-19 mortality and to determine the lethal risk levels of these predictors during the disease process. The dataset of the study consists of 38 routine blood values of 2597 patients who died (n = 233) and recovered (n = 2364) from COVID-19 in August-December, 2021. In this study, histogram-based gradient boosting (HGB) model was the most successful mashine learning classifier in detecting living and deceased COVID-19 patients (with squared F1 metrics F1^2 = 1). The most efficient binary combinations with procalcitonin were obtained with D-dimer, ESR, D.Bil and ferritin. The HGB model operated with these couples correctly detected almost all of the patients who survived and died. (precision > 0.98, recall > 0.98, F1^2 > 0.98). Furthermore, in the HGB model operated with a single feature, the most efficient features were Procalcitonin (F1^2 = 0.96) and ferritin (F1^2 = 0.91). In addition, according to the two-threshold approach ferritin values between 376.2 mkg/L and 396.0 mkg/L (F1^2 = 0.91) and procalcitonin values between 0.2 mkg/L and 5.2 mkg/L (F1^2 = 0.95) were found to be fatal risk levels for COVID-19. Considering all the results, we suggest that many features combined with these features, especially procalcitonin and ferritin, operated with the HGB model, can be used to achieve very successful results in the classification of those who live and die from COVID-19.Moreover, we strongly recommend that clinicians consider the critical levels we have found for procalcitonin and ferritin properties to reduce the lethality of COVID-19 disease.
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