Cube-Based 3D Denoising Diffusion Probabilistic Model for Cone Beam Computed Tomography Reconstruction with Incomplete Data
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Deep learning (DL) has been extensively researched in the field of computed tomography (CT) reconstruction with incomplete data, particularly in sparse-view CT reconstruction. However, applying DL to sparse-view cone beam CT (CBCT) remains challenging. Many models learn the mapping from sparse-view CT images to ground truth but struggle to achieve satisfactory performance in terms of global artifact removal. Incorporating sinogram data and utilizing dual-domain information can enhance anti-artifact performance, but this requires storing the entire sinogram in memory. This presents a memory issue for high-resolution CBCT sinograms, limiting further research and application. In this paper, we propose a cube-based 3D denoising diffusion probabilistic model (DDPM) for CBCT reconstruction using down-sampled data. A DDPM network, trained on cubes extracted from paired fully sampled sinograms and down-sampled sinograms, is employed to inpaint down-sampled sinograms. Our method divides the entire sinogram into overlapping cubes and processes these cubes in parallel using multiple GPUs, overcoming memory limitations. Experimental results demonstrate that our approach effectively suppresses few-view artifacts while preserving textural details faithfully.
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