Computing Quartet Distance is Equivalent to Counting 4-Cycles
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The quartet distance is a measure of similarity used to compare two unrooted phylogenetic trees on the same set of n leaves, defined as the number of subsets of four leaves related by a different topology in both trees. After a series of previous results, Brodal et al. [SODA 2013] presented an algorithm that computes this number in O(nd n) time, where d is the maximum degree of a node. Our main contribution is a two-way reduction establishing that the complexity of computing the quartet distance between two trees on n leaves is the same, up to polylogarithmic factors, as the complexity of counting 4-cycles in an undirected simple graph with m edges. The latter problem has been extensively studied, and the fastest known algorithm by Vassilevska Williams [SODA 2015] works in O(m^1.48) time. In fact, even for the seemingly simpler problem of detecting a 4-cycle, the best known algorithm works in O(m^4/3) time, and a conjecture of Yuster and Zwick implies that this might be optimal. In particular, an almost-linear time for computing the quartet distance would imply a surprisingly efficient algorithm for counting 4-cycles. In the other direction, by plugging in the state-of-the-art algorithms for counting 4-cycles, our reduction allows us to significantly decrease the complexity of computing the quartet distance. For trees with unbounded degrees we obtain an O(n^1.48) time algorithm, which is a substantial improvement on the previous bound of O(n^2 n). For trees with degrees bounded by d, by analysing the reduction more carefully, we are able to obtain an Õ(nd^0.77) time algorithm, which is again a nontrivial improvement on the previous bound of O(nd n).
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