Computational Enhancement of Molecularly Targeted Contrast-Enhanced Ultrasound: Application to Human Breast Tumor Imaging

06/22/2020
by   Andrew A. Berlin, et al.
0

Molecularly targeted contrast enhanced ultrasound (mCEUS) is a clinically promising approach for early cancer detection through targeted imaging of VEGFR2 (KDR) receptors. We have developed computational enhancement techniques for mCEUS tailored to address the unique challenges of imaging contrast accumulation in humans. These techniques utilize dynamic analysis to distinguish molecularly bound contrast agent from other contrast-mode signal sources, enabling analysis of contrast agent accumulation to be performed during contrast bolus arrival when the signal due to molecular binding is strongest. Applied to the 18 human patient examinations of the first-in-human molecular ultrasound breast lesion study, computational enhancement improved the ability to differentiate between pathology-proven lesion and pathology-proven normal tissue in real-world human examination conditions that involved both patient and probe motion, with improvements in contrast ratio between lesion and normal tissue that in most cases exceed an order of magnitude (10x). Notably, computational enhancement eliminated a false positive result in which tissue leakage signal was misinterpreted by radiologists to be contrast agent accumulation.

READ FULL TEXT
POST COMMENT

Comments

There are no comments yet.

Authors

page 1

page 3

page 7

page 8

09/14/2018

BPE and computer-extracted parenchymal enhancement for breast cancer risk, response monitoring, and prognosis

Functional behavior of breast cancer - representing underlying biology -...
03/09/2010

Investigation and Assessment of Disorder of Ultrasound B-mode Images

Digital image plays a vital role in the early detection of cancers, such...
06/14/2013

Unsupervised deconvolution of dynamic imaging reveals intratumor vascular heterogeneity

Intratumor heterogeneity is often manifested by vascular compartments wi...
09/27/2016

Automated Breast Lesion Segmentation in Ultrasound Images

The main objective of this project is to segment different breast ultras...
09/18/2018

Magnetic Navigation of a Rotating Colloidal Swarm Using Ultrasound Images

Microrobots are considered as promising tools for biomedical application...
08/05/2014

It is hard to see a needle in a haystack: Modeling contrast masking effect in a numerical observer

Within the framework of a virtual clinical trial for breast imaging, we ...
11/20/2018

Deep Unfolded Robust PCA with Application to Clutter Suppression in Ultrasound

Contrast enhanced ultrasound is a radiation-free imaging modality which ...
This week in AI

Get the week's most popular data science and artificial intelligence research sent straight to your inbox every Saturday.