Closed testing procedures for treatment-versus-control comparisons and multiple correlated endpoint

03/13/2021

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Preferably in two- or three-arm randomized clinical trials, a few (2,3) correlated multiple primary endpoints are considered. In addition to the closed testing principle based on different global tests, two max(maxT) tests are compared with respect to any-pairs, all-pairs and individual power in a simulation study.

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Closed testing procedures for treatment-versus-control comparisons and multiple correlated endpoint

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Closed testing procedures for treatment-versus-control comparisons and multiple correlated endpoint

Related Research

Comparisons of multiple treatment groups with a negative control or placebo group: Dunnett test vs. closed test procedur

A unified framework for weighted parametric group sequential design (WPGSD)

A Direct Approach to Simultaneous Tests of Superiority and Noninferiority with Multiple Endpoints

Simultaneous comparisons of treatments versus control (Dunnett-type tests) for location-scale alternatives

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