Closed test procedures for the comparison of dose groups against a negative control group or placebo

12/30/2020

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by   Ludwig A. Hothorn, et al.

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Dose groups are compared with a control assuming an order restriction usually by the Williams trend test. Here, as an alternative, two variants of the closed testing procedure are considered, one where global Williams tests are used in the partition hypotheses, and another where pairwise contrast tests are used for this purpose. Related R software is provided.