Classification of Epithelial Ovarian Carcinoma Whole-Slide Pathology Images Using Deep Transfer Learning
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Ovarian cancer is the most lethal cancer of the female reproductive organs. There are 5 major histological subtypes of epithelial ovarian cancer, each with distinct morphological, genetic, and clinical features. Currently, these histotypes are determined by a pathologist's microscopic examination of tumor whole-slide images (WSI). This process has been hampered by poor inter-observer agreement (Cohen's kappa 0.54-0.67). We utilized a two-stage deep transfer learning algorithm based on convolutional neural networks (CNN) and progressive resizing for automatic classification of epithelial ovarian carcinoma WSIs. The proposed algorithm achieved a mean accuracy of 87.54% and Cohen's kappa of 0.8106 in the slide-level classification of 305 WSIs; performing better than a standard CNN and pathologists without gynecology-specific training.
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