Bayesian Persuasion in Sequential Trials

10/18/2021
by   Shih-Tang Su, et al.
0

We consider a Bayesian persuasion or information design problem where the sender tries to persuade the receiver to take a particular action via a sequence of signals. This we model by considering multi-phase trials with different experiments conducted based on the outcomes of prior experiments. In contrast to most of the literature, we consider the problem with constraints on signals imposed on the sender. This we achieve by fixing some of the experiments in an exogenous manner; these are called determined experiments. This modeling helps us understand real-world situations where this occurs: e.g., multi-phase drug trials where the FDA determines some of the experiments, funding of a startup by a venture capital firm, start-up acquisition by big firms where late-stage assessments are determined by the potential acquirer, multi-round job interviews where the candidates signal initially by presenting their qualifications but the rest of the screening procedures are determined by the interviewer. The non-determined experiments (signals) in the multi-phase trial are to be chosen by the sender in order to persuade the receiver best. With a binary state of the world, we start by deriving the optimal signaling policy in the only non-trivial configuration of a two-phase trial with binary-outcome experiments. We then generalize to multi-phase trials with binary-outcome experiments where the determined experiments can be placed at any chosen node in the trial tree. Here we present a dynamic programming algorithm to derive the optimal signaling policy that uses the two-phase trial solution's structural insights. We also contrast the optimal signaling policy structure with classical Bayesian persuasion strategies to highlight the impact of the signaling constraints on the sender.

READ FULL TEXT

page 1

page 2

page 3

page 4

research
04/07/2023

SPOT: Sequential Predictive Modeling of Clinical Trial Outcome with Meta-Learning

Clinical trials are essential to drug development but time-consuming, co...
research
02/13/2023

Adaptive Cohort Size Determination Method for Bayesian Optimal Interval Phase I/II Design to Shorten Clinical Trial Duration

Recently, the strategy for dose optimization in oncology has shifted to ...
research
07/08/2021

A bayesian reanalysis of the phase III aducanumab (ADU) trial

In this article we have conducted a reanalysis of the phase III aducanum...
research
10/12/2022

Designing an exploratory phase 2b platform trial in NASH with correlated, co-primary binary endpoints

Non-alcoholic steatohepatitis (NASH), an inflammatory and more progressi...
research
06/21/2019

Leveraging Reinforcement Learning Techniques for Effective Policy Adoption and Validation

Rewards and punishments in different forms are pervasive and present in ...
research
02/08/2021

HINT: Hierarchical Interaction Network for Trial Outcome Prediction Leveraging Web Data

Clinical trials are crucial for drug development but are time consuming,...
research
06/24/2020

Design and Evaluation of Personalized Free Trials

Free trial promotions, where users are given a limited time to try the p...

Please sign up or login with your details

Forgot password? Click here to reset