Automated detection and quantification of COVID-19 airspace disease on chest radiographs: A novel approach achieving radiologist-level performance using a CNN trained on digita

Purpose: To leverage volumetric quantification of airspace disease (AD) derived from a superior modality (CT) serving as ground truth, projected onto digitally reconstructed radiographs (DRRs) to: 1) train a convolutional neural network to quantify airspace disease on paired CXRs; and 2) compare the DRR-trained CNN to expert human readers in the CXR evaluation of patients with confirmed COVID-19. Materials and Methods: We retrospectively selected a cohort of 86 COVID-19 patients (with positive RT-PCR), from March-May 2020 at a tertiary hospital in the northeastern USA, who underwent chest CT and CXR within 48 hrs. The ground truth volumetric percentage of COVID-19 related AD (POv) was established by manual AD segmentation on CT. The resulting 3D masks were projected into 2D anterior-posterior digitally reconstructed radiographs (DRR) to compute area-based AD percentage (POa). A convolutional neural network (CNN) was trained with DRR images generated from a larger-scale CT dataset of COVID-19 and non-COVID-19 patients, automatically segmenting lungs, AD and quantifying POa on CXR. CNN POa results were compared to POa quantified on CXR by two expert readers and to the POv ground-truth, by computing correlations and mean absolute errors. Results: Bootstrap mean absolute error (MAE) and correlations between POa and POv were 11.98 readers, and 9.56 respectively. Conclusion: Our CNN trained with DRR using CT-derived airspace quantification achieved expert radiologist level of accuracy in the quantification of airspace disease on CXR, in patients with positive RT-PCR for COVID-19.

READ FULL TEXT

page 26

page 27

page 28

research
06/09/2020

Automated Quantification of CT Patterns Associated with COVID-19 from Chest CT

Purpose: To present a method that automatically segments and quantifies ...
research
04/02/2020

Quantification of Tomographic Patterns associated with COVID-19 from Chest CT

Purpose: To present a method that automatically detects and quantifies a...
research
05/20/2021

Generation of COVID-19 Chest CT Scan Images using Generative Adversarial Networks

SARS-CoV-2, also known as COVID-19 or Coronavirus, is a viral contagious...
research
05/05/2020

3D Tomographic Pattern Synthesis for Enhancing the Quantification of COVID-19

The Coronavirus Disease (COVID-19) has affected 1.8 million people and r...
research
04/24/2020

How Reliable are Test Numbers for Revealing the COVID-19 Ground Truth and Applying Interventions?

The number of confirmed cases of COVID-19 is often used as a proxy for t...
research
11/16/2021

CNN Filter Learning from Drawn Markers for the Detection of Suggestive Signs of COVID-19 in CT Images

Early detection of COVID-19 is vital to control its spread. Deep learnin...
research
04/18/2021

CNN AE: Convolution Neural Network combined with Autoencoder approach to detect survival chance of COVID 19 patients

In this paper, we propose a novel method named CNN-AE to predict surviva...

Please sign up or login with your details

Forgot password? Click here to reset