Artificial Intelligence, speech and language processing approaches to monitoring Alzheimer's Disease: a systematic review

Language is a valuable source of clinical information in Alzheimer's Disease, as it declines concurrently with neurodegeneration. Consequently, speech and language data have been extensively studied in connection with its diagnosis. This paper summarises current findings on the use of artificial intelligence, speech and language processing to predict cognitive decline in the context of Alzheimer's Disease, detailing current research procedures, highlighting their limitations and suggesting strategies to address them. We conducted a systematic review of original research between 2000 and 2019, registered in PROSPERO (reference CRD42018116606). An interdisciplinary search covered six databases on engineering (ACM and IEEE), psychology (PsycINFO), medicine (PubMed and Embase) and Web of Science. Bibliographies of relevant papers were screened until December 2019. From 3,654 search results 51 articles were selected against the eligibility criteria. Four tables summarise their findings: study details (aim, population, interventions, comparisons, methods and outcomes), data details (size, type, modalities, annotation, balance, availability and language of study), methodology (pre-processing, feature generation, machine learning, evaluation and results) and clinical applicability (research implications, clinical potential, risk of bias and strengths/limitations). While promising results are reported across nearly all 51 studies, very few have been implemented in clinical research or practice. We concluded that the main limitations of the field are poor standardisation, limited comparability of results, and a degree of disconnect between study aims and clinical applications. Attempts to close these gaps should support translation of future research into clinical practice.

READ FULL TEXT
research
09/02/2021

Artificial Intelligence in Dry Eye Disease

Dry eye disease (DED) has a prevalence of between 5 and 50%, depending o...
research
10/13/2020

Machine learning for the diagnosis of Parkinson's disease: A systematic review

Diagnosis of Parkinson's disease (PD) is commonly based on medical obser...
research
03/24/2023

Lay Text Summarisation Using Natural Language Processing: A Narrative Literature Review

Summarisation of research results in plain language is crucial for promo...
research
07/19/2023

Alzheimer's Disease Detection from Spontaneous Speech and Text: A review

In the past decade, there has been a surge in research examining the use...
research
12/16/2022

Natural Language Processing in Customer Service: A Systematic Review

Artificial intelligence and natural language processing (NLP) are increa...
research
07/04/2020

A Modern Non-SQL Approach to Radiology-Centric Search Engine Design with Clinical Validation

Healthcare data is increasing in size at an unprecedented speed with muc...

Please sign up or login with your details

Forgot password? Click here to reset