Artificial Intelligence Assistance Significantly Improves Gleason Grading of Prostate Biopsies by Pathologists

02/11/2020
by   Wouter Bulten, et al.
0

While the Gleason score is the most important prognostic marker for prostate cancer patients, it suffers from significant observer variability. Artificial Intelligence (AI) systems, based on deep learning, have proven to achieve pathologist-level performance at Gleason grading. However, the performance of such systems can degrade in the presence of artifacts, foreign tissue, or other anomalies. Pathologists integrating their expertise with feedback from an AI system could result in a synergy that outperforms both the individual pathologist and the system. Despite the hype around AI assistance, existing literature on this topic within the pathology domain is limited. We investigated the value of AI assistance for grading prostate biopsies. A panel of fourteen observers graded 160 biopsies with and without AI assistance. Using AI, the agreement of the panel with an expert reference standard significantly increased (quadratically weighted Cohen's kappa, 0.799 vs 0.872; p=0.018). Our results show the added value of AI systems for Gleason grading, but more importantly, show the benefits of pathologist-AI synergy.

READ FULL TEXT

page 8

page 9

page 12

research
04/09/2020

ConsciousControlFlow(CCF): A Demonstration for conscious Artificial Intelligence

In this demo, we present ConsciousControlFlow(CCF), a prototype system t...
research
02/06/2018

Augmented Artificial Intelligence

All artificial Intelligence (AI) systems make errors. These errors are u...
research
07/02/2019

Pathologist-Level Grading of Prostate Biopsies with Artificial Intelligence

Background: An increasing volume of prostate biopsies and a world-wide s...
research
02/26/2023

Comparing Sentence-Level Suggestions to Message-Level Suggestions in AI-Mediated Communication

Traditionally, writing assistance systems have focused on short or even ...
research
04/04/2020

BlackBox Toolkit: Intelligent Assistance to UI Design

User Interface (UI) design is an creative process that involves consider...
research
11/06/2022

Examining the Differential Risk from High-level Artificial Intelligence and the Question of Control

Artificial Intelligence (AI) is one of the most transformative technolog...
research
11/14/2022

A taxonomic system for failure cause analysis of open source AI incidents

While certain industrial sectors (e.g., aviation) have a long history of...

Please sign up or login with your details

Forgot password? Click here to reset