Analysis of Growing Tumor on the Flow Velocity of Cerebrospinal Fluid in Human Brain Using Computational Modeling and Fluid-Structure Interaction

by   Muhammad Uzair-Ul-Haq, et al.

Cerebrospinal fluid (CSF) plays a pivotal role in normal functioning of Brain. Intracranial compartments such as blood, brain and CSF are incompressible in nature. Therefore, if a volume imbalance in one of the aforenoted compartments is observed, the other reaches out to maintain net change to zero. Whereas, CSF has higher compliance over long term. However, if the CSF flow is obstructed in the ventricles, this compliance may get exhausted early. Brain tumor on the other hand poses a similar challenge towards destabilization of CSF flow by compressing any section of ventricles thereby ensuing obstruction. To avoid invasive procedures to study effects of tumor on CSF flow, numerical-based methods such as Finite element modeling (FEM) are used which provide excellent description of underlying pathological interaction. A 3D fluid-structure interaction (FSI) model is developed to study the effect of tumor growth on the flow of cerebrospinal fluid in ventricle system. The FSI model encapsulates all the physiological parameters which may be necessary in analyzing intraventricular CSF flow behavior. Findings of the model show that brain tumor affects CSF flow parameters by deforming the walls of ventricles in this case accompanied by a mean rise of 74.23 velocity and considerable deformation on the walls of ventricles.



There are no comments yet.


page 12


Non-Newtonian and poroelastic effects in simulations of arterial flows

In this paper, we focus on investigating the influence on hydrodynamic f...

Validation and parameter optimization of a hybrid embedded/homogenized solid tumor perfusion model

The goal of this paper is to investigate the validity of a hybrid embedd...

Fully Automatic Brain Tumor Segmentation using a Normalized Gaussian Bayesian Classifier and 3D Fluid Vector Flow

Brain tumor segmentation from Magnetic Resonance Images (MRIs) is an imp...

A reduced 3D-0D FSI model of the aortic valve including leaflets curvature

In the present work, we propose a novel lumped-parameter model for the d...

Visualizing Carotid Blood Flow Simulations for Stroke Prevention

In this work, we investigate how concepts from medical flow visualizatio...

Modeling blood flow in networks of viscoelastic vessels with the 1D augmented fluid-structure interaction system

A noteworthy aspect in blood flow modeling is the definition of the mech...
This week in AI

Get the week's most popular data science and artificial intelligence research sent straight to your inbox every Saturday.