An Application of PC-AiR Method for Population Structure Inference in the Presence of Sample Relatedness

05/07/2018

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by   Bochao Jia, et al.

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In this paper, we introduce the PC-AiR method for robust inference of population structure when there exist related individuals. We describe the PC-AiR approach in detail and especially examine the shrinkage phenomenon when predicting the PC scores. To evaluate the performance and compare it with other methods, we apply it as well as competing methods in a simulation study and two real datasets.