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A statistical method for estimating the no-observed-adverse-event-level

01/02/2021

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by Ludwig A. Hothorn, et al.

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In toxicological risk assessment the benchmark dose (BMD) is recommended instead of the no-observed-adverse effect-level (NOAEL). Still a simple test procedure to estimate NOAEL is proposed here, explaining its advantages and disadvantages. Versatile applicability is illustrated using four different data examples of selected in vivo toxicity bioassays.

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