A Multi-parameter regression model for interval censored survival data

01/28/2019

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by   Defen Peng, et al.

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We develop flexible multi-parameter regression survival models for interval censored survival data arising in longitudinal prospective studies and longitudinal randomised controlled clinical trials. A multi-parameter Weibull regression survival model, which is wholly parametric, and has non-proportional hazards, is the main focus of the paper. We describe the basic model, develop the interval-censored likelihood and extend the model to include gamma frailty and a dispersion model. We evaluate the models by means of a simulation study and a detailed re-analysis of data from the Signal Tandmobiel^ study. The results demonstrate that the multi-parameter regression model with frailty is computationally efficient and provides an excellent fit to the data.