A Flexible Joint Longitudinal-Survival Modeling Framework for Incorporating Multiple Longitudinal Biomarkers

07/26/2018

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by   Sepehr Akhavan-Masouleh, et al.

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We are interested in survival analysis of hemodialysis patients for whom several biomarkers are recorded over time. Motivated by this challenging problem, we propose a general framework for multivariate joint longitudinal-survival modeling that can be used to examine the association between several longitudinally recorded covariates and a time-to-event endpoint. Our method allows for simultaneous modeling of longitudinal covariates by taking their correlation into account. This leads to a more efficient method for modeling their trajectories over time, and hence, it can better capture their relationship to the survival outcomes.